PMID- 33150732
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1939-3806 (Electronic)
IS  - 1939-3806 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Jan
TI  - A Neuroimaging Preparation Protocol Tailored for Autism.
PG  - 65-74
LID - 10.1002/aur.2427 [doi]
AB  - This paper describes the key basic elements required for a successful 
      multi-parametric MRI data acquisition in awake children with autism. The 
      procedure was designed by taking into account methodological challenges arising 
      from the acquisition of Resting State fMRI (RS fMRI) data, and factors such as 
      cost, time, and staff availability. The ultimate aim was to prepare an imaging 
      preparation protocol with high transferability to the whole autism spectrum, 
      adaptable for use in a multi-site research with multiple time points. As part of 
      a randomized pharmaco-intervention study, 31 children aged 4-10 years with 
      Neurofibromatosis 1 and autism underwent MR imaging at baseline and end of 
      intervention. The protocol consisted of tailored habituation instructions 
      including gradual exposure to scanner noise, a social stories booklet, positive 
      incentive strategies, and Play Therapy support. Success rate for initial 
      acquisition was 71% for GABA+ MR spectroscopy at either location, 87% for 
      perfusion, and 67% for diffusion assessment, and 71% for RS fMRI. Qualitative 
      data indicated that 84% parents found the habituation protocol helpful. LAY 
      SUMMARY: Here we describe a protocol for brain Magnetic Resonance Imaging (MRI) 
      tailored for children with ASD to help reduce stress and avoid sedation during 
      scanning. This procedure can make advanced medical imaging more accessible and 
      promote a better MRI experience for families of children with ASD.
CI  - © 2020 International Society for Autism Research and Wiley Periodicals LLC.
FAU - Tziraki, Maria
AU  - Tziraki M
AUID- ORCID: 0000-0003-3297-3942
AD  - Psychology Department, CITY College, International Faculty of the University of 
      Sheffield, Thessaloniki, Greece.
FAU - Garg, Shruti
AU  - Garg S
AD  - Division of Neuroscience & Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 
      Manchester, UK.
AD  - Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
FAU - Harrison, Emma
AU  - Harrison E
AD  - NIHR Clinical Research Facility, Royal Manchester Children's Hospital, Manchester 
      University NHS Foundation Trust, Manchester, UK.
FAU - Wright, Neville B
AU  - Wright NB
AD  - Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
FAU - Hawkes, Rob
AU  - Hawkes R
AD  - Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
FAU - Akhtar, Kapasi
AU  - Akhtar K
AD  - Division of Neuroscience & Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 
      Manchester, UK.
FAU - Green, Jonathan
AU  - Green J
AD  - Division of Neuroscience & Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, University of Manchester, 
      Manchester, UK.
AD  - Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
FAU - Stivaros, Stavros
AU  - Stivaros S
AD  - Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
AD  - Division of Informatics, Imaging and Data Sciences, School of Health Sciences, 
      University of Manchester & Academic Unit of Paediatric Radiology, Royal 
      Manchester Children's Hospital, Manchester University NHS Foundation Trust, 
      Manchester, UK.
LA  - eng
GR  - G0600485/MRC_/Medical Research Council/United Kingdom
GR  - NIHR/CS/010/021/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20201104
PL  - United States
TA  - Autism Res
JT  - Autism research : official journal of the International Society for Autism 
      Research
JID - 101461858
SB  - IM
MH  - *Autism Spectrum Disorder/diagnostic imaging
MH  - *Autistic Disorder/diagnostic imaging
MH  - Brain/diagnostic imaging
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neuroimaging
OTO - NOTNLM
OT  - MRI
OT  - NF1
OT  - autism
OT  - fMRI
OT  - scanning protocol
OT  - spectroscopy
EDAT- 2020/11/06 06:00
MHDA- 2021/06/23 06:00
CRDT- 2020/11/05 06:13
PHST- 2020/05/14 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/10/21 00:00 [accepted]
PHST- 2020/11/06 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/11/05 06:13 [entrez]
AID - 10.1002/aur.2427 [doi]
PST - ppublish
SO  - Autism Res. 2021 Jan;14(1):65-74. doi: 10.1002/aur.2427. Epub 2020 Nov 4.