Poptsi, Eleni & Tsatali, Marianna & Agogiatou, Christina & Bakoglidou, Evaggelia & Batsila, Georgia & Dellaporta, Dionysia & Kounti-Zafeiropoulou, Fotini & Liapi, Despoina & Lysitsas, Konstantinos & Markou, Nefeli & Mouzakidis, Christos & Ouzouni, Fani & Papasozomenou, Chrysa & Soumpourou, Aikaterini & Vasiloglou, Maria & Zafeiropoulos, Stavros & Tsolaki, Magda. (2021). Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer's Hellas Day Care Centre. Journal of geriatric psychiatry and neurology. 35. 8919887211016057. 10.1177/08919887211016057. 


This study assesses the effectiveness of a multicomponent Longitudinal Cognitive Training (CT) program plus physical exercise (PE) for people with Mild Cognitive Impairment (MCI). 155 people with MCI, completed a 3 years (3Y) CT+PE, whilst 133 were control. Neuropsychological assessment was performed at baseline and 3 years later, whilst CT+PE had additional annual assessments. According to the results, the 3Y CT+PE outperformed control in cognitive abilities (p < 0.002), and Activities of Daily Living (ADL) (p < 0.001), stabilized their functional performances between 1st and 2nd year, but worsened in working and verbal memory between 2nd and 3 rd year (p < 0.002). Control deteriorated in cognitive functions (p < 0.001) and ADL (p < 0.001) after 3 years, whilst 1.33% of the experimental and 13.53% of the control group progressed to dementia (p < 0.001). Longitudinal CT+PE improves cognitive performance and ADL in MCI and delay the progression to dementia.